The Efficacy, Side Effects, and Usage Guide for Revolution® and Revolution® Plus for Cats
The Efficacy, Side Effects, and Usage Guide for Revolution® and Revolution® Plus for Cats
I. Introduction to Revolution® for Cats
Revolution® is a topical flea, heartworm, intestinal worm, ear mite, and tick treatment for cats developed by Pfizer. It is available as a spot-on solution and contains Selamectin as its active ingredient.
II. Mechanism of Action of Selamectin
Selamectin is a macrocyclic lactone insecticide that acts on glutamate-gated chloride channels in the nerve synapses of insects and internal parasites (roundworms). It keeps the channels open, allowing chloride ions to flow continuously, disrupting nerve signal transmission and ultimately paralyzing the parasite.
Fleas: Adult fleas die quickly after ingesting Selamectin, which is distributed in hair follicles and sebaceous glands.
Heartworms: Selamectin kills heartworm larvae when they come into contact with tissues and blood vessels.
Roundworms: Selamectin enters the intestines through exudates and kills roundworms.
Ear Mites: Selamectin enters ear canal tissues through exudates and ultimately kills ear mites.
III. Safety and Side Effects of Selamectin
While Selamectin can bind to nerve cells in mammals, it cannot cross the blood-brain barrier. Therefore, it does not contact the central nervous system and does not cause toxic symptoms. It is considered a relatively safe ingredient. Extensive clinical trials have shown that Selamectin is well-tolerated by cats, with few side effects. The side effects are usually mild and include salivation, vomiting, etc. These symptoms generally disappear on their own within a short period.
IV. Usage Guide for Revolution® for Cats
Applicable range: Suitable for cats aged 6 weeks and older, regardless of weight.
Method of use: Part the fur and apply directly to the skin, usually between the shoulder blades in the neck area.
Dosage: Determine the dosage based on the cat's weight. The minimum effective dose is 6 mg per kilogram of body weight.
Frequency of use: Due to the duration of effect of about one month, it is recommended to use it once a month.
Precautions:
Ensure the skin and fur are dry before applying the medication.
Do not touch the application site immediately after applying the medication to avoid contact with the skin.
Do not bathe the cat for 2 hours after application.
Strictly follow the instructions and dosage to avoid overdose.
V. Efficacy of Revolution® for Cats
Numerous studies have confirmed that Revolution® has a good effect on various parasites in cats, including:
Fleas: Highly effective in killing fleas and can effectively prevent flea allergy dermatitis.
Heartworms: Effective in preventing heartworm infection and killing larvae.
Ear Mites: Effective in treating ear mite infections and preventing recurrence.
Roundworms: Effective in expelling various roundworms in cats, including roundworms and hookworms.
VI. Introduction to Revolution® Plus for Cats
Revolution® Plus is an extension of Revolution® that adds Saroranel as an active ingredient. Besides preventing heartworm, roundworm, flea, lice, ear mite infections, it can also effectively eliminate hookworms and ticks.
VII. Mechanism of Action of Saroranel
Saroranel is an isoxazoline antiparasitic drug that acts on GABA-gated chloride channels in arthropods. It inhibits chloride ions from entering nerve cells, causing overexcitation and ultimately killing fleas and ticks.
VIII. Safety and Side Effects of Saroranel
Saroranel has been developed to specifically bind to nerve cells in arthropods and is considered a relatively safe ingredient for mammals, including humans, dogs, and cats. However, some studies have shown that in rare cases, Saroranel may cause neurological side effects such as tremors and ataxia.
IX. Usage Guide for Revolution® Plus for Cats
Applicable range: Suitable for cats aged 6 weeks and older, weighing 1.3 kg or more.
Method of use: Same as Revolution®, part the fur and apply directly to the skin, usually between the shoulder blades in the neck area.
Dosage: Determine the dosage based on the cat's weight. The minimum effective dose is 6 mg Selamectin and 1 mg Saroranel per kilogram of body weight.
Frequency of use: Due to the duration of effect of about one month, it is recommended to use it once a month.
Precautions:
Ensure the skin and fur are dry before applying the medication.
Do not touch the application site immediately after applying the medication to avoid contact with the skin.
Do not bathe the cat for 24 hours after application.
Strictly follow the instructions and dosage to avoid overdose.
Safety for cats that are going to mate or are pregnant or lactating has not been established.
X. Efficacy of Revolution® Plus for Cats
Hookworms: Saroranel can effectively eliminate hookworm infection in cats.
Ticks: Saroranel also has a killing effect on ticks, but its effect may not be as significant as on other parasites.
XI. Summary of Experience in Using Revolution® and Revolution® Plus
1. Regular use: To ensure the best effect of parasite control, it is recommended to use Revolution® or Revolution® Plus regularly once a month, especially during the peak season for fleas, heartworms, and other parasites.
2. Observe the cat's reaction: After using the medication, carefully observe the cat's reaction. If any abnormalities occur, such as salivation, vomiting, tremors, etc., stop using the medication immediately and consult a veterinarian.
3. Prevention is better than cure: Regular use of anti-parasitic medication can effectively prevent parasitic infection and protect cats from harm caused by parasites.
4. Choose the right anti-parasitic medication: Choose the appropriate anti-parasitic medication based on the cat's age, weight, type of parasite, etc., and use it strictly according to the instructions.
5. Maintain cat hygiene: Regularly bathing, grooming, and cleaning the environment can effectively reduce the breeding of parasites.
I. Introduction to Revolution® for Cats
Revolution® is a topical flea, heartworm, intestinal worm, ear mite, and tick treatment for cats developed by Pfizer. It is available as a spot-on solution and contains Selamectin as its active ingredient.
II. Mechanism of Action of Selamectin
Selamectin is a macrocyclic lactone insecticide that acts on glutamate-gated chloride channels in the nerve synapses of insects and internal parasites (roundworms). It keeps the channels open, allowing chloride ions to flow continuously, disrupting nerve signal transmission and ultimately paralyzing the parasite.
Fleas: Adult fleas die quickly after ingesting Selamectin, which is distributed in hair follicles and sebaceous glands.
Heartworms: Selamectin kills heartworm larvae when they come into contact with tissues and blood vessels.
Roundworms: Selamectin enters the intestines through exudates and kills roundworms.
Ear Mites: Selamectin enters ear canal tissues through exudates and ultimately kills ear mites.
III. Safety and Side Effects of Selamectin
While Selamectin can bind to nerve cells in mammals, it cannot cross the blood-brain barrier. Therefore, it does not contact the central nervous system and does not cause toxic symptoms. It is considered a relatively safe ingredient. Extensive clinical trials have shown that Selamectin is well-tolerated by cats, with few side effects. The side effects are usually mild and include salivation, vomiting, etc. These symptoms generally disappear on their own within a short period.
IV. Usage Guide for Revolution® for Cats
Applicable range: Suitable for cats aged 6 weeks and older, regardless of weight.
Method of use: Part the fur and apply directly to the skin, usually between the shoulder blades in the neck area.
Dosage: Determine the dosage based on the cat's weight. The minimum effective dose is 6 mg per kilogram of body weight.
Frequency of use: Due to the duration of effect of about one month, it is recommended to use it once a month.
Precautions:
Ensure the skin and fur are dry before applying the medication.
Do not touch the application site immediately after applying the medication to avoid contact with the skin.
Do not bathe the cat for 2 hours after application.
Strictly follow the instructions and dosage to avoid overdose.
V. Efficacy of Revolution® for Cats
Numerous studies have confirmed that Revolution® has a good effect on various parasites in cats, including:
Fleas: Highly effective in killing fleas and can effectively prevent flea allergy dermatitis.
Heartworms: Effective in preventing heartworm infection and killing larvae.
Ear Mites: Effective in treating ear mite infections and preventing recurrence.
Roundworms: Effective in expelling various roundworms in cats, including roundworms and hookworms.
VI. Introduction to Revolution® Plus for Cats
Revolution® Plus is an extension of Revolution® that adds Saroranel as an active ingredient. Besides preventing heartworm, roundworm, flea, lice, ear mite infections, it can also effectively eliminate hookworms and ticks.
VII. Mechanism of Action of Saroranel
Saroranel is an isoxazoline antiparasitic drug that acts on GABA-gated chloride channels in arthropods. It inhibits chloride ions from entering nerve cells, causing overexcitation and ultimately killing fleas and ticks.
VIII. Safety and Side Effects of Saroranel
Saroranel has been developed to specifically bind to nerve cells in arthropods and is considered a relatively safe ingredient for mammals, including humans, dogs, and cats. However, some studies have shown that in rare cases, Saroranel may cause neurological side effects such as tremors and ataxia.
IX. Usage Guide for Revolution® Plus for Cats
Applicable range: Suitable for cats aged 6 weeks and older, weighing 1.3 kg or more.
Method of use: Same as Revolution®, part the fur and apply directly to the skin, usually between the shoulder blades in the neck area.
Dosage: Determine the dosage based on the cat's weight. The minimum effective dose is 6 mg Selamectin and 1 mg Saroranel per kilogram of body weight.
Frequency of use: Due to the duration of effect of about one month, it is recommended to use it once a month.
Precautions:
Ensure the skin and fur are dry before applying the medication.
Do not touch the application site immediately after applying the medication to avoid contact with the skin.
Do not bathe the cat for 24 hours after application.
Strictly follow the instructions and dosage to avoid overdose.
Safety for cats that are going to mate or are pregnant or lactating has not been established.
X. Efficacy of Revolution® Plus for Cats
Hookworms: Saroranel can effectively eliminate hookworm infection in cats.
Ticks: Saroranel also has a killing effect on ticks, but its effect may not be as significant as on other parasites.
XI. Summary of Experience in Using Revolution® and Revolution® Plus
1. Regular use: To ensure the best effect of parasite control, it is recommended to use Revolution® or Revolution® Plus regularly once a month, especially during the peak season for fleas, heartworms, and other parasites.
2. Observe the cat's reaction: After using the medication, carefully observe the cat's reaction. If any abnormalities occur, such as salivation, vomiting, tremors, etc., stop using the medication immediately and consult a veterinarian.
3. Prevention is better than cure: Regular use of anti-parasitic medication can effectively prevent parasitic infection and protect cats from harm caused by parasites.
4. Choose the right anti-parasitic medication: Choose the appropriate anti-parasitic medication based on the cat's age, weight, type of parasite, etc., and use it strictly according to the instructions.
5. Maintain cat hygiene: Regularly bathing, grooming, and cleaning the environment can effectively reduce the breeding of parasites.
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